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Issue 36, 2012
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Ru(II) sensitized lanthanide luminescence: synthesis, photophysical properties, and near-infrared luminescent determination of alpha-fetal protein (AFP)

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Abstract

A series of dinuclear compounds of [Ru(bpy)2(tpphz)Ln(TTA)3](PF6)2 (tpphz = tetrapyrido[3,2-a:2′,3′-c:3′′,2′′-h:3′′′,4′′′-j]phenazine; Ln = Er(III), Nd(III), Yb(III) and Gd(III); TTA = 2-thenoyltrifluoroacetone) have been prepared by attachment of a [Ln(TTA)3] fragment at the vacant diimine site of the luminescent mononuclear complex [Ru(bpy)2(tpphz)](PF6)2. In the solid state, in CH2Cl2 solution and in Tris-HCl buffer solution of these dinuclear complexes Ru–Ln, sensitized near-infrared (NIR) luminescence is observed from Nd and Yb centres following excitation of the d-block unit, which results from the effective Ru → Ln (Ln = Nd, Yb) energy transfer, but no Er-based NIR luminescence is produced. The 3MLCT (MLCT = metal to ligand charge transfer) emission is partly quenched in the Ru–Nd complex, slightly increased in the Ru–Yb complex, and is not changed in the Ru–Er complex. Interestingly, alpha-fetal protein (AFP) tends to decrease the NIR luminescence intensity of the Ru–Nd complex in Tris-HCl buffer solution. A novel NIR luminescent method for the determination of AFP was developed with a linear range of 0.5–18 ng mL−1, and a detection limit of 0.2 ng mL−1 based on 3 times the ratio of the signal-to-noise. Considering the attractive features, such as good selectivity, stability and rapidity, the proposed NIR luminescent method provides promising potential for AFP detection in clinical diagnosis and biomedical applications.

Graphical abstract: Ru(ii) sensitized lanthanide luminescence: synthesis, photophysical properties, and near-infrared luminescent determination of alpha-fetal protein (AFP)

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Publication details

The article was received on 04 May 2012, accepted on 11 Jul 2012 and first published on 11 Jul 2012


Article type: Paper
DOI: 10.1039/C2DT30974B
Citation: Dalton Trans., 2012,41, 11219-11225
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    Ru(II) sensitized lanthanide luminescence: synthesis, photophysical properties, and near-infrared luminescent determination of alpha-fetal protein (AFP)

    Q. Wei, Y. Lei, W. Xu, J. Xie and G. Chen, Dalton Trans., 2012, 41, 11219
    DOI: 10.1039/C2DT30974B

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