Jump to main content
Jump to site search

Issue 23, 2012
Previous Article Next Article

Structural features of mono- and tri-nuclear Zn(II) complexes with a non-steroidal anti-inflammatory drug as ligand

Author affiliations

Abstract

The interaction of Zn(II) with the non-steroidal anti-inflammatory drug tolfenamic acid leads to the formation of the structurally characterized trinuclear [Zn3(tolfenamato)6(CH3OH)2] complex. In the presence of the N,N′-donor heterocyclic ligands 1,10-phenanthroline and 2,2′-bipyridine at a range of ratios, the mononuclear Zn complexes of the general formulae [Zn(tolfenamato)(N,N′-donor)Cl] and [Zn(tolfenamato)2(N,N′-donor)] have been isolated and structurally characterized by X-ray crystallography. The deprotonated tolfenamato ligands are coordinated to the Zn(II) ion through carboxylato oxygen atoms. Tolfenamic acid and its complexes exhibit good binding propensity to human or bovine serum albumin protein having relatively high binding constant values.

Graphical abstract: Structural features of mono- and tri-nuclear Zn(ii) complexes with a non-steroidal anti-inflammatory drug as ligand

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Mar 2012, accepted on 04 Apr 2012 and first published on 04 Apr 2012


Article type: Paper
DOI: 10.1039/C2DT30547J
Citation: Dalton Trans., 2012,41, 7082-7091
  •   Request permissions

    Structural features of mono- and tri-nuclear Zn(II) complexes with a non-steroidal anti-inflammatory drug as ligand

    A. Tarushi, X. Totta, C. P. Raptopoulou, V. Psycharis, G. Psomas and D. P. Kessissoglou, Dalton Trans., 2012, 41, 7082
    DOI: 10.1039/C2DT30547J

Search articles by author

Spotlight

Advertisements