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Issue 20, 2012
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A novel quinoline-based two-photon fluorescent probe for detecting Cd2+in vitro and in vivo

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Abstract

A new two-photon fluorescent Cd2+ probe APQ is developed by introducing a N1,N1-dimethyl-N2-(pyridin-2-ylmethyl)ethane-1,2-diamine binding group and a 4-methoxyphenylvinyl conjugation-enhancing group to the 2- and 6-positions of quinoline. This probe shows a large red shift and good emission enhancement under Cd2+ binding. It also exhibits a high ion selectivity for Cd2+ (especially over Zn2+) and a large two-photon absorption cross section at 710 nm. Two-photon microscopy imaging studies reveal that the new probe is non-toxic and cell-permeable and can be used to detect intracellular Cd2+ under two-photon excitation.

Graphical abstract: A novel quinoline-based two-photon fluorescent probe for detecting Cd2+in vitro and in vivo

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Publication details

The article was received on 26 Jan 2012, accepted on 05 Apr 2012 and first published on 10 Apr 2012


Article type: Paper
DOI: 10.1039/C2DT30192J
Citation: Dalton Trans., 2012,41, 6189-6194
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    A novel quinoline-based two-photon fluorescent probe for detecting Cd2+in vitro and in vivo

    Y. Li, H. Chong, X. Meng, S. Wang, M. Zhu and Q. Guo, Dalton Trans., 2012, 41, 6189
    DOI: 10.1039/C2DT30192J

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