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Issue 10, 2012
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Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes

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Abstract

3-Hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) is a successful iron chelator, which has been widely investigated for its activity in mitigating iron overload and in protecting against oxidative stress due to Reactive Oxygen Species (ROS). Herein, we present the synthesis, characterisation, physicochemical properties and antioxidant activity of two novel bioconjugates of β-cyclodextrin bearing the deferiprone moiety either on the upper rim (1) or on the lower rim (2) of the cyclodextrin and their iron(III) complexes. Protonation and iron stability constants were measured by spectrophotometric titration for the two systems and antioxidant activity studied for both the ligands and the iron(III) complexes.

Graphical abstract: Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(iii) complexes

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Publication details

The article was received on 05 Sep 2011, accepted on 24 Oct 2011 and first published on 30 Nov 2011


Article type: Paper
DOI: 10.1039/C1DT11677K
Citation: Dalton Trans., 2012,41, 2877-2883
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    Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes

    A. Puglisi, J. Spencer, V. Oliveri, G. Vecchio, X. Kong, J. Clarke and J. Milton, Dalton Trans., 2012, 41, 2877
    DOI: 10.1039/C1DT11677K

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