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Issue 2, 2012
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Kinetic study of nickel-thiolate oxygenation by hydrogen peroxide. Implications for nickel-containing superoxide dismutase

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Abstract

The rate of metal-thiolate oxygenation by hydrogen peroxide has been measured for a model complex of nickel-containing superoxide dismutase (NiSOD) as 0.47 ± 0.03 M−1 s−1 at 303 K. Under typical synthetic conditions the reaction proceeds within seconds yielding S-oxygenate products. At biologically relevant H2O2 concentrations, half-life times extend to several hours or days. The results suggest H2O2 oxidation of NiSOD is not kinetically competent on the SOD timescale accounting for the lack of S-oxygenation byproducts.

Graphical abstract: Kinetic study of nickel-thiolate oxygenation by hydrogen peroxide. Implications for nickel-containing superoxide dismutase

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Publication details

The article was received on 07 Jul 2011, accepted on 21 Oct 2011 and first published on 22 Nov 2011


Article type: Communication
DOI: 10.1039/C1DT11300C
Citation: Dalton Trans., 2012,41, 364-366
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    Kinetic study of nickel-thiolate oxygenation by hydrogen peroxide. Implications for nickel-containing superoxide dismutase

    D. R. Herdt and C. A. Grapperhaus, Dalton Trans., 2012, 41, 364
    DOI: 10.1039/C1DT11300C

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