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Issue 8, 2012
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Asymmetric, biocatalytic labeled compound synthesis using transaminases

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Abstract

The use of transaminases for the incorporation of deuterium and tritium in chiral amines starting from prochiral ketone precursors has been demonstrated. Efficient labeling was demonstrated using a variety of ketone substrates. Amplification of the labeled product was observed, with tritium incorporation enriched up to 2.8X the statistically expected levels of labeling.

Graphical abstract: Asymmetric, biocatalytic labeled compound synthesis using transaminases

  • This article is part of the themed collection: Biocatalysis
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Publication details

The article was received on 24 Feb 2012, accepted on 19 Mar 2012 and first published on 20 Mar 2012


Article type: Communication
DOI: 10.1039/C2CY20110K
Citation: Catal. Sci. Technol., 2012,2, 1556-1559
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    Asymmetric, biocatalytic labeled compound synthesis using transaminases

    M. Truppo, J. M. Janey, B. Grau, K. Morley, S. Pollack, G. Hughes and I. Davies, Catal. Sci. Technol., 2012, 2, 1556
    DOI: 10.1039/C2CY20110K

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