The use of transaminases for the incorporation of deuterium and tritium in chiral amines starting from prochiral ketone precursors has been demonstrated. Efficient labeling was demonstrated using a variety of ketone substrates. Amplification of the labeled product was observed, with tritium incorporation enriched up to 2.8X the statistically expected levels of labeling.
Fetching data from CrossRef. This may take some time to load.
Catalysis Science & Technology
- Information Point