Jump to main content
Jump to site search

Issue 8, 2012
Previous Article Next Article

Ruthenium(II) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

Author affiliations

Abstract

In the last few decades, coordination complexes based on d6 metal centres and polypyridyl ligand architectures been developed as structure- and site-specific reversible DNA binding agents. Due to their attractive photophysical properties, much of this research has focused on complexes based on ruthenium(II) centres and, more recently, attention has turned to the use of these complexes in biological contexts. As the rules that govern the cellular uptake and cellular localisation of such systems are determined they are finding numerous applications ranging from imaging to therapeutics. This review illustrates how the interdisciplinary nature of this research—which takes in synthetic chemistry, biophysical and in cellulo studies—makes this an exciting area in which an array of further applications are likely to emerge.

Graphical abstract: Ruthenium(ii) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 06 Nov 2011 and first published on 07 Feb 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS15299A
Citation: Chem. Soc. Rev., 2012,41, 3179-3192
  •   Request permissions

    Ruthenium(II) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

    M. R. Gill and J. A. Thomas, Chem. Soc. Rev., 2012, 41, 3179
    DOI: 10.1039/C2CS15299A

Search articles by author