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Issue 7, 2012
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Silica-based nanoprobes for biomedical imaging and theranostic applications

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Abstract

Nanoparticle-based contrast agents are attracting a great deal of attention for various biomedical imaging and theranostic applications. Compared to conventional contrast agents, nanoparticles possess several potential advantages to improve in vivo detection and to enhance targeting efficiency. Silica-based nanoprobes can be engineered to achieve longer blood circulation times, specific clearance pathways, and multivalent binding. In this tutorial review, we summarize the latest progress on designing silica-based nanoprobes for imaging and theranostic applications. The synthesis of both solid silica and mesoporous silica nanoparticles is described, along with different approaches used for surface functionalization. Special emphasis is placed on the application of silica-based nanoprobes in optical, magnetic resonance, and multimodal imaging. The latest breakthroughs in the applications of silica nanoparticles as theranostic agents are also highlighted.

Graphical abstract: Silica-based nanoprobes for biomedical imaging and theranostic applications

  • This article is part of the themed collection: Nanomedicine
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Publication details

The article was received on 27 Aug 2011 and first published on 10 Jan 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS15229K
Citation: Chem. Soc. Rev., 2012,41, 2673-2685
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    Silica-based nanoprobes for biomedical imaging and theranostic applications

    J. L. Vivero-Escoto, R. C. Huxford-Phillips and W. Lin, Chem. Soc. Rev., 2012, 41, 2673
    DOI: 10.1039/C2CS15229K

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