without changing your settings we'll assume you are happy to receive all RSC cookies.
You can change your cookie settings by navigating to our Privacy and Cookies page and following the instructions. These instructions
are also obtainable from the privacy link at the bottom of any RSC page.
2,5-Piperazinediones (2,5-diketopiperazines, DKPs) can be viewed as privileged building blocks for the synthesis of heterocyclic systems. This tutorial review aims at underscoring the large number and structural variety of nitrogen heterocycles that are available by suitable manipulation of DKP starting materials, including many bioactive compounds and natural products.
A tutorial review, with 53 references, of 2,5-piperazidones as starting materials for the synthesis of heterocycles. Transformations of the system via reactions of the carbonyl groups, ring opening, aza-Wittig reactions, condensations, Dieckmann cyclisations, reductions, Heck reactions, Pictet–Spengler reactions, alkylations, arylations, rearrangements etc. deliver a large variety of heterocyclic compounds with biological or pharmacological significance.
Fetching data from CrossRef. This may take some time to load.