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Issue 17, 2012
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“Common synthetic scaffolds” in the synthesis of structurally diverse natural products

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Abstract

Selected natural products have long been considered as desirable targets for total synthesis due to their unique biological properties and their challenging structural complexity. Laboratory synthesis of natural compounds usually relies on target-oriented synthesis, involving the production, isolation and purification of successive intermediates, requiring multiple steps to arrive to the final product. A far more economical approach using common synthetic scaffolds that can be readily transformed through biomimetic-like pathways to a range of structurally diverse natural products has been evolved in the last decade, leading synthesis to new directions. This tutorial review critically presents the hallmarks in this field.

Graphical abstract: “Common synthetic scaffolds” in the synthesis of structurally diverse natural products

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Publication details

The article was received on 15 Mar 2012 and first published on 10 Jul 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS35080G
Citation: Chem. Soc. Rev., 2012,41, 5613-5625
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    “Common synthetic scaffolds” in the synthesis of structurally diverse natural products

    E. E. Anagnostaki and A. L. Zografos, Chem. Soc. Rev., 2012, 41, 5613
    DOI: 10.1039/C2CS35080G

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