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Issue 4, 2012
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Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis

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Abstract

This critical review presents an introduction to biocatalysis for synthetic chemists. Advances in biocatalysis of the past 5 years illustrate the breadth of applications for these powerful and selective catalysts in conducting key reaction steps. Asymmetric synthesis of value-added targets and other reaction types are covered, with an emphasis on pharmaceutical intermediates and bulk chemicals. Resources of interest for the non-initiated are provided, including specialized websites and service providers to facilitate identification of suitable biocatalysts, as well as references to recent volumes and reviews for more detailed biocatalytic procedures. Challenges related to the application of biocatalysts are discussed, including how ‘green’ a biocatalytic reaction may be, and trends in biocatalyst improvement through enzyme engineering are presented (152 references).

Graphical abstract: Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis

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Publication details

The article was received on 20 Oct 2011 and first published on 10 Jan 2012


Article type: Critical Review
DOI: 10.1039/C2CS15286J
Citation: Chem. Soc. Rev., 2012,41, 1585-1605
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    Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis

    C. M. Clouthier and J. N. Pelletier, Chem. Soc. Rev., 2012, 41, 1585
    DOI: 10.1039/C2CS15286J

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