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Issue 3, 2012
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Recent developments in the field of oxa-Michael reactions

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Abstract

Oxa-Michael reactions, i.e. addition reactions of oxygen nucleophiles to conjugated systems, have traditionally received much less attention from the scientific community compared to the addition of carbon nucleophiles to conjugate acceptor systems (Michael reaction). This was mainly due to lack of reactivity and selectivity of these reactions. Within the last few years however, there has been a remarkable increase in publications focussing on method development as well as applications to natural product synthesis. This tutorial review discusses instructive examples that have substantially broadened the scope of oxa-Michael reactions.

Graphical abstract: Recent developments in the field of oxa-Michael reactions

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Publication details

The article was received on 20 Jun 2011 and first published on 28 Jul 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15167C
Citation: Chem. Soc. Rev., 2012,41, 988-999
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    Recent developments in the field of oxa-Michael reactions

    C. F. Nising and S. Bräse, Chem. Soc. Rev., 2012, 41, 988
    DOI: 10.1039/C1CS15167C

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