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Issue 2, 2012
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Organocatalytic synthesis of carbohydrates

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Abstract

The key role of carbohydrates in biological processes and their visible existence in our everyday life have stimulated the interest of leading research groups on the smart and simple synthesis of common and rare sugar molecules. Now, more than 120 years after Fischer's first synthesis of (D)-glucose (1890), we are witnessing important development in this field of total synthesis. Using modern methods of direct activation of carbonyl compounds chemists can prepare sugars in an elegant and efficient way similar to that of Nature. This tutorial review presents recent impressive progress in the area of de novo synthesis of carbohydrates by using organocatalytic direct aldol reaction as a key step.

Graphical abstract: Organocatalytic synthesis of carbohydrates

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Publication details

The article was received on 27 May 2011 and first published on 28 Jul 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15144D
Citation: Chem. Soc. Rev., 2012,41, 587-596
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    Organocatalytic synthesis of carbohydrates

    J. Mlynarski and B. Gut, Chem. Soc. Rev., 2012, 41, 587
    DOI: 10.1039/C1CS15144D

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