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Issue 27, 2012
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Homo- and heteronuclear two-dimensional covariance solid-state NMR spectroscopy with a dual-receiver system

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Abstract

Two-dimensional (2D) covariance NMR spectroscopy, which has originally been established to extract homonuclear correlations (HOMCOR), is extended to include heteronuclear correlations (HETCOR). In a 13C/15N 2D chemical shift correlation experiment, 13C and 15N signals of a polycrystalline sample of 13C, 15N-labeled amino acid are acquired simultaneously using a dual-receiver NMR system. The data sets are rearranged for the covariance data processing, and the 13C–15N heteronuclear correlations are obtained together with the 13C–13C and 15N–15N homonuclear correlations. The present approach retains the favorable feature of the original covariance HOMCOR that the spectral resolution along the indirect dimension is given by that of the detection dimension. As a result, much fewer amounts of data are required to obtain a well-resolved 2D spectrum compared to the case of the conventional 2D Fourier-Transformation (FT) scheme. Hence, one can significantly save the experimental time, or enhance the sensitivity by increasing the number of signal averaging within a given measurement time.

Graphical abstract: Homo- and heteronuclear two-dimensional covariance solid-state NMR spectroscopy with a dual-receiver system

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Publication details

The article was received on 13 Apr 2012, accepted on 11 May 2012 and first published on 14 May 2012


Article type: Paper
DOI: 10.1039/C2CP41191A
Citation: Phys. Chem. Chem. Phys., 2012,14, 9715-9721
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    Homo- and heteronuclear two-dimensional covariance solid-state NMR spectroscopy with a dual-receiver system

    K. Takeda, Y. Kusakabe, Y. Noda, M. Fukuchi and K. Takegoshi, Phys. Chem. Chem. Phys., 2012, 14, 9715
    DOI: 10.1039/C2CP41191A

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