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Issue 99, 2012
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One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

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Abstract

Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.

Graphical abstract: One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

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Publication details

The article was received on 11 Sep 2012, accepted on 29 Oct 2012 and first published on 30 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36613D
Citation: Chem. Commun., 2012,48, 12100-12102
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    One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

    V. Štrukil, B. Bartolec, T. Portada, I. Đilović, I. Halasz and D. Margetić, Chem. Commun., 2012, 48, 12100
    DOI: 10.1039/C2CC36613D

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