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Issue 100, 2012
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Structural basis of single molecular heparin–FX06 interaction revealed by SPM measurements and molecular simulations

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Abstract

Heparin, a functionalized polysaccharide, is observed under a scanning tunneling microscope, which shows atomic scale conformational details. The peptide FX06 is found to bind to five consecutive sugar units of heparin and this interaction is directly revealed by atomic force microscopy and dynamic force spectroscopy measurements. The determined free energy change agrees well with the dynamic calculation result.

Graphical abstract: Structural basis of single molecular heparin–FX06 interaction revealed by SPM measurements and molecular simulations

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Publication details

The article was received on 08 Sep 2012, accepted on 01 Nov 2012 and first published on 02 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC36546D
Citation: Chem. Commun., 2012,48, 12222-12224
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    Structural basis of single molecular heparin–FX06 interaction revealed by SPM measurements and molecular simulations

    C. Guo, B. Wang, L. Wang and B. Xu, Chem. Commun., 2012, 48, 12222
    DOI: 10.1039/C2CC36546D

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