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Issue 94, 2012
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CuAAC click functionalization of azide-modified nanodiamond with a photoactivatable CO-releasing molecule (PhotoCORM) based on [Mn(CO)3(tpm)]+

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Abstract

The copper-catalyzed 1,3-dipolar azide–alkyne cycloaddition (CuAAC) was used for the first time to attach a biologically active carbon monoxide delivery agent to modified nanodiamond (ND) as a highly biocompatible carrier. The [Mn(CO)3(tpm)]+ photoactivatable CO-releasing molecule (PhotoCORM) on the surface retained the carbon monoxide release properties of the parent compound as shown with the myoglobin assay.

Graphical abstract: CuAAC click functionalization of azide-modified nanodiamond with a photoactivatable CO-releasing molecule (PhotoCORM) based on [Mn(CO)3(tpm)]+

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Publication details

The article was received on 05 Sep 2012, accepted on 09 Oct 2012 and first published on 09 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36491C
Citation: Chem. Commun., 2012,48, 11528-11530
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    CuAAC click functionalization of azide-modified nanodiamond with a photoactivatable CO-releasing molecule (PhotoCORM) based on [Mn(CO)3(tpm)]+

    G. Dördelmann, T. Meinhardt, T. Sowik, A. Krueger and U. Schatzschneider, Chem. Commun., 2012, 48, 11528
    DOI: 10.1039/C2CC36491C

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