An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay

Xinjian Yang; Fang Pu; Cuie Chen; Jinsong Ren; Xiaogang Qu

doi:10.1039/C2CC36340B

An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay

Xinjian Yang,^a^b Fang Pu,^a Cuie Chen,^a Jinsong Ren*^a and Xiaogang Qu^a

* Corresponding authors

^a State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
E-mail: jren@ciac.jl.cn

^b Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

Abstract

Based on selective pore-opening in the presence of protease, we have developed a novel signal amplification assay for multiple proteases detection and their inhibition using protein-capped mesoporous scaffolding as the substrate.

Supplementary files

Publication details

The article was received on 31 Aug 2012, accepted on 26 Sep 2012 and first published on 27 Sep 2012

Article type: Communication

DOI: 10.1039/C2CC36340B

Citation: Chem. Commun., 2012,48, 11133-11135

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An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay

X. Yang, F. Pu, C. Chen, J. Ren and X. Qu, Chem. Commun., 2012, 48, 11133
DOI: 10.1039/C2CC36340B
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Chemical Communications

An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay

Abstract

Supplementary files

Publication details

An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay

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