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Issue 91, 2012
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Flow synthesis of arylboronic esters bearing electrophilic functional groups and space integration with Suzuki–Miyaura coupling without intentionally added base

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Abstract

We found that an integrated flow microreactor system enables the preparation of boronic esters bearing electrophilic functional groups using organolithium chemistry and that it allows for their use in Suzuki–Miyaura cross-coupling without intentionally added base. Based on this method, cross-coupling of two aryl halides bearing electrophilic functional groups was accomplished to obtain the corresponding biaryl compounds in one flow.

Graphical abstract: Flow synthesis of arylboronic esters bearing electrophilic functional groups and space integration with Suzuki–Miyaura coupling without intentionally added base

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Publication details

The article was received on 26 Aug 2012, accepted on 27 Sep 2012 and first published on 28 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC36197C
Citation: Chem. Commun., 2012,48, 11211-11213
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    Flow synthesis of arylboronic esters bearing electrophilic functional groups and space integration with Suzuki–Miyaura coupling without intentionally added base

    A. Nagaki, Y. Moriwaki and J. Yoshida, Chem. Commun., 2012, 48, 11211
    DOI: 10.1039/C2CC36197C

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