Issue 98, 2012
From the journal:

Chemical Communications

A label-free electrical detection of exosomal microRNAs using microelectrode array†

Tatsuro Goda,a   Kozue Masuno,a   Junko Nishida,a   Nobuyoshi Kosaka,b   Takahiro Ochiya,b   Akira Matsumotoa  and  Yuji Miyahara*a  

* Corresponding authors

a Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Japan
E-mail: miyahara@tmd.ac.jp
Fax: +81 3 5280 8095
Tel: +81 3 5280 8097

b Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Japan

Abstract

We report a method for detecting microRNAs encapsulated in exosomes using a microelectrode array in semiconductor-based potentiometry after RT-PCR. The inherent miniaturization of the electrical biosensor meets requirements for massively parallel analysis of circulating microRNA as a noninvasive biomarker.

Graphical abstract: A label-free electrical detection of exosomal microRNAs using microelectrode array

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Article information

DOI
https://doi.org/10.1039/C2CC36111F
Article type
Communication
Submitted
22 Aug 2012
Accepted
04 Oct 2012
First published
05 Oct 2012

Chem. Commun., 2012,48, 11942-11944

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A label-free electrical detection of exosomal microRNAs using microelectrode array

T. Goda, K. Masuno, J. Nishida, N. Kosaka, T. Ochiya, A. Matsumoto and Y. Miyahara, Chem. Commun., 2012, 48, 11942 DOI: 10.1039/C2CC36111F

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