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Issue 92, 2012
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First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

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Abstract

We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP5 mimics 5-PP-InsP5 binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.

Graphical abstract: First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

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Publication details

The article was received on 20 Aug 2012, accepted on 14 Sep 2012 and first published on 18 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC36044F
Citation: Chem. Commun., 2012,48, 11292-11294
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    First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

    A. M. Riley, H. Wang, J. D. Weaver, S. B. Shears and B. V. L. Potter, Chem. Commun., 2012, 48, 11292
    DOI: 10.1039/C2CC36044F

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