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Issue 83, 2012
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An efficient labeling strategy of drug like molecules with functionalized alkyl linkers using CH-activation

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Abstract

Heterocyclic drugs can be cross-coupled with functionalized thiophene derivatives under dehydrogenative conditions using Pd-catalysts. Upon reductive desulfurization an alkyl linker is introduced with a functional group at its terminus, which will allow the immobilization of the drug molecule onto a solid support for chemical proteomics.

Graphical abstract: An efficient labeling strategy of drug like molecules with functionalized alkyl linkers using CH-activation

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Publication details

The article was received on 08 Aug 2012, accepted on 05 Sep 2012 and first published on 06 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35758E
Citation: Chem. Commun., 2012,48, 10343-10345
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    An efficient labeling strategy of drug like molecules with functionalized alkyl linkers using CH-activation

    J. Rentner and R. Breinbauer, Chem. Commun., 2012, 48, 10343
    DOI: 10.1039/C2CC35758E

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