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Issue 85, 2012
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Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities

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Abstract

Crystal structures of polymorphs and solvatomorphs of the potential anxiolytic drug fenobam exhibit an exclusive preference for one of the two possible tautomeric structures. A novel methodology based on nonlinear optical response has been successfully employed to detect the presence of a polymorphic impurity in a mixture of polymorphs.

Graphical abstract: Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities

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Publication details

The article was received on 09 Jul 2012, accepted on 10 Sep 2012 and first published on 11 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC34912D
Citation: Chem. Commun., 2012,48, 10559-10561
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    Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities

    S. P. Thomas, K. Nagarajan and T. N. G. Row, Chem. Commun., 2012, 48, 10559
    DOI: 10.1039/C2CC34912D

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