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Issue 78, 2012
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Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence

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Abstract

Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagen-stimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in β-sheet content at high temperature.

Graphical abstract: Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence

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Publication details

The article was received on 29 Jun 2012, accepted on 12 Aug 2012 and first published on 13 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34665F
Citation: Chem. Commun., 2012,48, 9774-9776
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    Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence

    P. Palladino, V. Castelletto, A. Dehsorkhi, D. Stetsenko and I. W. Hamley, Chem. Commun., 2012, 48, 9774
    DOI: 10.1039/C2CC34665F

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