Issue 70, 2012
From the journal:

Chemical Communications

Homogeneous electrochemical monitoring of exonuclease III activity and its application to nucleic acid testing by target recycling†

Rebeca Miranda-Castro,a   Damien Marchal,a   Benoît Limoges*a  and  François Mavré*a  

* Corresponding authors

a Laboratoire d'Electrochimie Moléculaire, UMR 7591 CNRS, Université Paris Diderot, Sorbonne Paris Cité, 15 rue Jean-Antoine de Baïf, F-75205 Paris Cedex 13, France
E-mail: francois.mavre@univ-paris-diderot.fr
Fax: +33 157278788
Tel: +33 157278789

Abstract

A simple and fast electrochemical nucleic acid assay based on a target recycling strategy and the release of a double-stranded DNA intercalating redox probe upon digestion of a specific duplex by exonuclease III is demonstrated.

Graphical abstract: Homogeneous electrochemical monitoring of exonuclease III activity and its application to nucleic acid testing by target recycling

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Article information

DOI
https://doi.org/10.1039/C2CC34511K
Article type
Communication
Submitted
23 Jun 2012
Accepted
04 Jul 2012
First published
05 Jul 2012

Chem. Commun., 2012,48, 8772-8774

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Homogeneous electrochemical monitoring of exonuclease III activity and its application to nucleic acid testing by target recycling

R. Miranda-Castro, D. Marchal, B. Limoges and F. Mavré, Chem. Commun., 2012, 48, 8772 DOI: 10.1039/C2CC34511K

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