Issue 68, 2012
From the journal:

Chemical Communications

Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides†

Katsuhiko Moriyama,*a   Kazuma Ishidaa  and  Hideo Togo*a  

* Corresponding authors

a Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage-ku, Japan
E-mail: moriyama@faculty.chiba-u.jp, togo@faculty.chiba-u.jp

Abstract

The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.

Graphical abstract: Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides

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Article information

DOI
https://doi.org/10.1039/C2CC33914E
Article type
Communication
Submitted
31 May 2012
Accepted
04 Jul 2012
First published
05 Jul 2012

Chem. Commun., 2012,48, 8574-8576

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Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides

K. Moriyama, K. Ishida and H. Togo, Chem. Commun., 2012, 48, 8574 DOI: 10.1039/C2CC33914E

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