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Issue 68, 2012
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Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides

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Abstract

The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.

Graphical abstract: Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides

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Publication details

The article was received on 31 May 2012, accepted on 04 Jul 2012 and first published on 05 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC33914E
Citation: Chem. Commun., 2012,48, 8574-8576
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    Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides

    K. Moriyama, K. Ishida and H. Togo, Chem. Commun., 2012, 48, 8574
    DOI: 10.1039/C2CC33914E

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