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Issue 66, 2012
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Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

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Abstract

Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

Graphical abstract: Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

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Publication details

The article was received on 29 May 2012, accepted on 25 Jun 2012 and first published on 26 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC33855F
Citation: Chem. Commun., 2012,48, 8219-8221
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    Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

    D. Braga, F. Grepioni, L. Maini, D. Capucci, S. Nanna, J. Wouters, L. Aerts and L. Quéré, Chem. Commun., 2012, 48, 8219
    DOI: 10.1039/C2CC33855F

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