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Issue 77, 2012
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Hybridization and reaction-based fluorogenic nucleic acid probes

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Abstract

We developed fluorogenic probes, which are photoactivated in the presence of specific nucleic acid templates with the release of fluorescent dyes. This templated reaction can be used to target specific nucleic acids in complex mixtures. We further demonstrate that this reaction can be monitored by single-molecule fluorescence imaging.

Graphical abstract: Hybridization and reaction-based fluorogenic nucleic acid probes

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Publication details

The article was received on 28 May 2012, accepted on 07 Aug 2012 and first published on 08 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC33827K
Citation: Chem. Commun., 2012,48, 9664-9666
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    Hybridization and reaction-based fluorogenic nucleic acid probes

    S. Dutta, B. Flottmann, M. Heilemann and A. Mokhir, Chem. Commun., 2012, 48, 9664
    DOI: 10.1039/C2CC33827K

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