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Issue 60, 2012
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Sequence-specific inhibition of a designed metallopeptide catalyst

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Abstract

Rhodium metallopeptides catalyze proximity-driven modification of peptide and protein substrates with enzyme-like selectivity. In this communication, we demonstrate that designed metallopeptide catalysts can be inhibited in a sequence-specific manner, mimicking the inhibition and regulation of natural enzymes. We demonstrate sub-micromolar inhibition by a histidine-containing inhibitor peptide, taking advantage of cooperative supramolecular assembly and inorganic coordination.

Graphical abstract: Sequence-specific inhibition of a designed metallopeptide catalyst

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Publication details

The article was received on 04 May 2012, accepted on 09 Jun 2012 and first published on 13 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC33808D
Citation: Chem. Commun., 2012,48, 7492-7494
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    Sequence-specific inhibition of a designed metallopeptide catalyst

    B. V. Popp, Z. Chen and Z. T. Ball, Chem. Commun., 2012, 48, 7492
    DOI: 10.1039/C2CC33808D

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