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Issue 59, 2012
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Palladium-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion: synthesis of 2-substituted 1H-indole-3-carboxamides

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Abstract

A base-controlled synthesis of 2-substituted secondary and tertiary 1H-indole-3-carboxamides through PdCl2-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion has been developed. The reaction proceeds smoothly at ambient temperature using O2 in air as the sole oxidant of the palladium catalyst.

Graphical abstract: Palladium-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion: synthesis of 2-substituted 1H-indole-3-carboxamides

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Publication details

The article was received on 12 May 2012, accepted on 30 May 2012 and first published on 13 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC33435F
Citation: Chem. Commun., 2012,48, 7371-7373
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    Palladium-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion: synthesis of 2-substituted 1H-indole-3-carboxamides

    Z. Hu, D. Liang, J. Zhao, J. Huang and Q. Zhu, Chem. Commun., 2012, 48, 7371
    DOI: 10.1039/C2CC33435F

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