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Issue 67, 2012
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Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme

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Abstract

In this work we studied how backbone chemical modifications, such as 2′-O-methyl, phosphorothioate, L-form nucleotides and locked nucleic acid, on G-quadruplex based DNAzymes would affect their peroxidase activity. Our results indicate that 2′-O-methyl modification facilitates the formation of a perfectly compacted parallel structure and significantly promotes peroxidase activity of G-quadruplex based DNAzymes.

Graphical abstract: Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme

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Publication details

The article was received on 24 Apr 2012, accepted on 28 Jun 2012 and first published on 29 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC32919K
Citation: Chem. Commun., 2012,48, 8347-8349
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    Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme

    C. Li, L. Zhu, Z. Zhu, H. Fu, G. Jenkins, C. Wang, Y. Zou, X. Lu and C. J. Yang, Chem. Commun., 2012, 48, 8347
    DOI: 10.1039/C2CC32919K

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