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Issue 53, 2012
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Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

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Abstract

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

Graphical abstract: Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

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Publication details

The article was received on 05 Apr 2012, accepted on 09 May 2012 and first published on 10 May 2012


Article type: Communication
DOI: 10.1039/C2CC32442C
Citation: Chem. Commun., 2012,48, 6699-6701
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    Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

    J. I. Ambrus, J. I. Halliday, N. Kanizaj, N. Absalom, K. Harpsøe, T. Balle, M. Chebib and M. D. McLeod, Chem. Commun., 2012, 48, 6699
    DOI: 10.1039/C2CC32442C

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