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Issue 66, 2012
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Structure and nuclease resistance of 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-ethyl (cEt) modified DNAs

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Abstract

Combining the structural elements of the second generation 2′-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2′,4′-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.

Graphical abstract: Structure and nuclease resistance of 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-ethyl (cEt) modified DNAs

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Publication details

The article was received on 30 Mar 2012, accepted on 27 Apr 2012 and first published on 27 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC32286B
Citation: Chem. Commun., 2012,48, 8195-8197
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    Structure and nuclease resistance of 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-ethyl (cEt) modified DNAs

    P. S. Pallan, C. R. Allerson, A. Berdeja, P. P. Seth, E. E. Swayze, T. P. Prakash and M. Egli, Chem. Commun., 2012, 48, 8195
    DOI: 10.1039/C2CC32286B

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