Issue 47, 2012
From the journal:

Chemical Communications

Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging†

Aneta J. Mieszawska,a   Anita Gianella,a   David P. Cormode,a   Yiming Zhao,b   Andries Meijerink,b   Robert Langer,c   Omid C. Farokhzad,d   Zahi A. Fayada  and  Willem J. M. Mulder*a  

* Corresponding authors

a Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, USA
E-mail: willem.mulder@mssm.edu
Fax: +1 212 534 2683
Tel: +1 212 241 7717

b Condensed Matter and Interfaces, Utrecht University, The Netherlands

c Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

d Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham & Women's Hospital, Boston, MA, USA

Abstract

Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate polymers modified with nanocrystals. The PLGA nanoparticles formed from modified PLGA polymers that were functionalized with either gold nanocrystals or quantum dots exhibited favorable features for computed tomography and optical imaging, respectively.

Graphical abstract: Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

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Article information

DOI
https://doi.org/10.1039/C2CC32149A
Article type
Communication
Submitted
23 Mar 2012
Accepted
16 Apr 2012
First published
03 May 2012

Chem. Commun., 2012,48, 5835-5837

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Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

A. J. Mieszawska, A. Gianella, D. P. Cormode, Y. Zhao, A. Meijerink, R. Langer, O. C. Farokhzad, Z. A. Fayad and W. J. M. Mulder, Chem. Commun., 2012, 48, 5835 DOI: 10.1039/C2CC32149A

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