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Issue 47, 2012
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Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

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Abstract

Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate polymers modified with nanocrystals. The PLGA nanoparticles formed from modified PLGA polymers that were functionalized with either gold nanocrystals or quantum dots exhibited favorable features for computed tomography and optical imaging, respectively.

Graphical abstract: Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

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Publication details

The article was received on 23 Mar 2012, accepted on 16 Apr 2012 and first published on 03 May 2012


Article type: Communication
DOI: 10.1039/C2CC32149A
Citation: Chem. Commun., 2012,48, 5835-5837
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    Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

    A. J. Mieszawska, A. Gianella, D. P. Cormode, Y. Zhao, A. Meijerink, R. Langer, O. C. Farokhzad, Z. A. Fayad and W. J. M. Mulder, Chem. Commun., 2012, 48, 5835
    DOI: 10.1039/C2CC32149A

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