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Issue 59, 2012
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Panorama of DNA hairpin folding observed via diffusion-decelerated fluorescence correlation spectroscopy

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Abstract

Based on a confocal microscopy platform, we extended the FCS time window by three orders of magnitude to the s timescale by attaching a polystyrene microsphere. We simultaneously monitored the relaxations of multiple intermediates involved in DNA hairpin folding, thus offering a much more detailed view of the kinetics of hairpin folding experimentally.

Graphical abstract: Panorama of DNA hairpin folding observed via diffusion-decelerated fluorescence correlation spectroscopy

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Publication details

The article was received on 19 Mar 2012, accepted on 06 Jun 2012 and first published on 08 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC31986A
Citation: Chem. Commun., 2012,48, 7413-7415
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    Panorama of DNA hairpin folding observed via diffusion-decelerated fluorescence correlation spectroscopy

    Y. Yin, P. Wang, X. X. Yang, X. Li, C. He and X. S. Zhao, Chem. Commun., 2012, 48, 7413
    DOI: 10.1039/C2CC31986A

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