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Issue 45, 2012
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Sequence-specific synthesis of macromolecules using DNA-templated chemistry

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Abstract

Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.

Graphical abstract: Sequence-specific synthesis of macromolecules using DNA-templated chemistry

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Publication details

The article was received on 18 Mar 2012, accepted on 16 Apr 2012 and first published on 17 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC31975F
Citation: Chem. Commun., 2012,48, 5614-5616
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    Sequence-specific synthesis of macromolecules using DNA-templated chemistry

    P. J. Milnes, M. L. McKee, J. Bath, L. Song, E. Stulz, A. J. Turberfield and R. K. O'Reilly, Chem. Commun., 2012, 48, 5614
    DOI: 10.1039/C2CC31975F

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