Jump to main content
Jump to site search

Issue 66, 2012
Previous Article Next Article

Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation

Author affiliations

Abstract

Prenylation is an essential post-translational modification in all eukaryotes. Here we describe the synthesis of a 340-member library of peptides containing free C-termini on cellulose membranes. The resulting library was then used to probe the specificity of protein farnesyltransferase from S. cerevisiae.

Graphical abstract: Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Mar 2012, accepted on 12 Jun 2012 and first published on 15 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC31713C
Citation: Chem. Commun., 2012,48, 8228-8230
  •   Request permissions

    Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation

    Y. Wang and M. D. Distefano, Chem. Commun., 2012, 48, 8228
    DOI: 10.1039/C2CC31713C

Search articles by author

Spotlight

Advertisements