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Issue 44, 2012
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A general method for detecting protease activity via gelation and its application to artificial clotting

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Abstract

A modular system for detecting protease activity via enzyme-triggered gel formation is described. Protease-specific recognition sequences are utilized to achieve enzyme specificity. Artificial blood clotting is demonstrated by activating endogenous thrombin to trigger gelation in fibrinogen-deficient blood plasma.

Graphical abstract: A general method for detecting protease activity via gelation and its application to artificial clotting

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Publication details

The article was received on 29 Feb 2012, accepted on 29 Mar 2012 and first published on 30 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC31537H
Citation: Chem. Commun., 2012,48, 5482-5484
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    A general method for detecting protease activity via gelation and its application to artificial clotting

    S. C. Bremmer, J. Chen, A. J. McNeil and M. B. Soellner, Chem. Commun., 2012, 48, 5482
    DOI: 10.1039/C2CC31537H

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