Issue 53, 2012
From the journal:

Chemical Communications

A heme degradation enzyme, HutZ, from Vibrio cholerae†‡

Takeshi Uchida,*ab   Yukari Sekine,b   Toshitaka Matsui,c   Masao Ikeda-Saitoc  and  Koichiro Ishimoriab  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan
E-mail: uchida@sci.hokudai.ac.jp
Fax: +81 11 706 3501
Tel: +81 706 3506

b Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Japan

c Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Sendai, Japan

Abstract

HutZ, one of the crucial proteins of the iron uptake system in Vibrio cholerae, was purified, which binds to heme at a stoichiometry of 1 : 1. In the presence of ascorbic acid, the HutZ-bound heme degrades via the same intermediates observed in heme oxygenase, suggesting that HutZ works as a heme degradation enzyme.

Graphical abstract: A heme degradation enzyme, HutZ, from Vibrio cholerae

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Article information

DOI
https://doi.org/10.1039/C2CC31147J
Article type
Communication
Submitted
15 Feb 2012
Accepted
08 May 2012
First published
08 May 2012

Chem. Commun., 2012,48, 6741-6743

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A heme degradation enzyme, HutZ, from Vibrio cholerae

T. Uchida, Y. Sekine, T. Matsui, M. Ikeda-Saito and K. Ishimori, Chem. Commun., 2012, 48, 6741 DOI: 10.1039/C2CC31147J

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