Jump to main content
Jump to site search

Issue 39, 2012
Previous Article Next Article

Regioselective heterohalogenation of 4-halo-anisoles via a series of sequential ortho-aluminations and electrophilic halogenations

Author affiliations

Abstract

As the aluminate base [LiAl(TMP)2(iBu)2] 1 displays halogen tolerance towards substituted aromatics, 4-halo-anisoles have been ortho-aluminated and electrophilically quenched to form synthetically useful multi-heterohalogenated anisoles, with the Al intermediates along the route structurally defined.

Graphical abstract: Regioselective heterohalogenation of 4-halo-anisoles via a series of sequential ortho-aluminations and electrophilic halogenations

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 03 Feb 2012, accepted on 15 Feb 2012 and first published on 16 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC30795B
Citation: Chem. Commun., 2012,48, 4674-4676
  •   Request permissions

    Regioselective heterohalogenation of 4-halo-anisoles via a series of sequential ortho-aluminations and electrophilic halogenations

    B. Conway, E. Crosbie, A. R. Kennedy, R. E. Mulvey and S. D. Robertson, Chem. Commun., 2012, 48, 4674
    DOI: 10.1039/C2CC30795B

Search articles by author