Jump to main content
Jump to site search

Issue 40, 2012
Previous Article Next Article

DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles

Author affiliations

Abstract

In an equimolar ratio the human telomeric oligonucleotides d[AGGG(TTAGGG)3] and d[(CCCTAA)3CCCT] formed mixed structures of duplex and tetraplex in bis(2-ethylhexyl)sulfosuccinate reverse micelles; only the duplex was observed in aqueous buffer. This finding suggests that heterogeneous confined media in the cell nucleus might induce a significant fraction of the telomeric region of genomic DNA to adopt non-canonical tetraplex structure.

Graphical abstract: DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Jan 2012, accepted on 09 Mar 2012 and first published on 09 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC30622K
Citation: Chem. Commun., 2012,48, 4815-4817
  •   Request permissions

    DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles

    S. Pramanik, S. Nagatoishi and N. Sugimoto, Chem. Commun., 2012, 48, 4815
    DOI: 10.1039/C2CC30622K

Search articles by author

Spotlight

Advertisements