Jump to main content
Jump to site search

Issue 27, 2012
Previous Article Next Article

Dioxindole in asymmetric catalytic synthesis: direct access to 3-substituted 3-hydroxy-2-oxindoles via 1,4-additions to nitroalkenes

Author affiliations

Abstract

The asymmetric Michael addition of dioxindoles to β-substituted nitroalkenes is reported. The bifunctional primary amine-thiourea A, by means of a non-covalent-based mode of catalysis, secures direct access to 3-substituted 3-hydroxyoxindole derivatives with high stereocontrol.

Graphical abstract: Dioxindole in asymmetric catalytic synthesis: direct access to 3-substituted 3-hydroxy-2-oxindoles via 1,4-additions to nitroalkenes

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Jan 2012, accepted on 11 Feb 2012 and first published on 13 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC30198A
Citation: Chem. Commun., 2012,48, 3336-3338
  •   Request permissions

    Dioxindole in asymmetric catalytic synthesis: direct access to 3-substituted 3-hydroxy-2-oxindoles via 1,4-additions to nitroalkenes

    M. Retini, G. Bergonzini and P. Melchiorre, Chem. Commun., 2012, 48, 3336
    DOI: 10.1039/C2CC30198A

Search articles by author

Spotlight

Advertisements