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Issue 47, 2012
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Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides

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Abstract

Disulfide- and terminal alkyne-modified magnetic silica particles (DA-MSPs) were synthesized and used to covalently capture and reductively release azido glycopeptides via click chemistry and dithiothreitol treatment. Using DA-MSPs, an efficient and specific enrichment method for separating azido glycopeptides has been developed.

Graphical abstract: Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides

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Publication details

The article was received on 30 Dec 2011, accepted on 17 Apr 2012 and first published on 18 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC18160F
Citation: Chem. Commun., 2012,48, 5907-5909
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    Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides

    S. Wang, W. Xie, X. Zhang, X. Zou and Y. Zhang, Chem. Commun., 2012, 48, 5907
    DOI: 10.1039/C2CC18160F

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