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Issue 42, 2012
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Bacterial CYP153A monooxygenases for the synthesis of omega-hydroxylated fatty acids

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Abstract

CYP153A from Marinobacter aquaeolei has been identified as a fatty acid ω-hydroxylase with a broad substrate range. Two hotspots predicted to influence substrate specificity and selectivity were exchanged. Mutant G307A is 2- to 20-fold more active towards fatty acids than the wild-type. Residue L354 is determinant for the enzyme ω-regioselectivity.

Graphical abstract: Bacterial CYP153A monooxygenases for the synthesis of omega-hydroxylated fatty acids

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Publication details

The article was received on 27 Dec 2011, accepted on 23 Mar 2012 and first published on 26 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC18103G
Citation: Chem. Commun., 2012,48, 5115-5117
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    Bacterial CYP153A monooxygenases for the synthesis of omega-hydroxylated fatty acids

    S. Honda Malca, D. Scheps, L. Kühnel, E. Venegas-Venegas, A. Seifert, B. M. Nestl and B. Hauer, Chem. Commun., 2012, 48, 5115
    DOI: 10.1039/C2CC18103G

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