Issue 29, 2012
From the journal:

Chemical Communications

Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs†

Peng Chen,a   Ming Gao,a   De-Xian Wang,a   Liang Zhaob  and  Mei-Xiang Wang*b  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

b The Key Laboratory for Organic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: wangmx@mail.tsinghua.edu.cn
Fax: +8610 6279 6761
Tel: +8610 6279 7527

Abstract

Amidase-catalyzed desymmetrization of meso-N-heterocyclic dicarboxamides under very mild conditions provided a highly efficient and practical method for the preparation of enantiomerically pure carbamoyl-substituted heterocyclic amino acids that were unique and versatile platforms for the construction of both antipodes of aza-sugar containing nucleoside analogs.

Graphical abstract: Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs

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Article information

DOI
https://doi.org/10.1039/C2CC18012J
Article type
Communication
Submitted
22 Dec 2011
Accepted
28 Jan 2012
First published
30 Jan 2012

Chem. Commun., 2012,48, 3482-3484

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Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs

P. Chen, M. Gao, D. Wang, L. Zhao and M. Wang, Chem. Commun., 2012, 48, 3482 DOI: 10.1039/C2CC18012J

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