Issue 24, 2012
From the journal:

Chemical Communications

Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction†

Hemakesh Mohapatra,a   Kyle M. Schmida  and  Scott T. Phillips*a  

* Corresponding authors

a The Pennsylvania State University, 104 Chemistry Bldg., University Park, USA
E-mail: sphillips@psu.edu
Fax: 814 865 5235
Tel: 814 867 2502

Abstract

This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay for palladium.

Graphical abstract: Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction

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Article information

DOI
https://doi.org/10.1039/C2CC17566E
Article type
Communication
Submitted
03 Dec 2011
Accepted
26 Jan 2012
First published
30 Jan 2012

Chem. Commun., 2012,48, 3018-3020

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Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction

H. Mohapatra, K. M. Schmid and S. T. Phillips, Chem. Commun., 2012, 48, 3018 DOI: 10.1039/C2CC17566E

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