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Issue 25, 2012
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Catalytic metallodrugs targeting HCV IRES RNA

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Abstract

A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with KM of 0.85 μM, kcat of 0.53 min−1, and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC50) of 0.58 μM in an HCV cellular replicon assay.

Graphical abstract: Catalytic metallodrugs targeting HCV IRES RNA

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Publication details

The article was received on 25 Nov 2011, accepted on 12 Jan 2012 and first published on 16 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC17377H
Citation: Chem. Commun., 2012,48, 3118-3120
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    Catalytic metallodrugs targeting HCV IRES RNA

    S. Bradford and J. A. Cowan, Chem. Commun., 2012, 48, 3118
    DOI: 10.1039/C2CC17377H

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