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Issue 18, 2012
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Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

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Abstract

We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa–GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.

Graphical abstract: Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

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Publication details

The article was received on 20 Nov 2011, accepted on 04 Jan 2012 and first published on 06 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC17223B
Citation: Chem. Commun., 2012,48, 2400-2402
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    Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

    A. Curcio, R. Marotta, A. Riedinger, D. Palumberi, A. Falqui and T. Pellegrino, Chem. Commun., 2012, 48, 2400
    DOI: 10.1039/C2CC17223B

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