Jump to main content
Jump to site search

Issue 18, 2012
Previous Article Next Article

Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening

Author affiliations

Abstract

Botulinum neurotoxins are one of the most poisonous biological substances known to humans and present a potential bioterrorism threat. There are no therapeutic interventions developed so far. Here, we report the first small molecule non-peptide inhibitor for botulinum neurotoxin serotype E discovered by structure-based virtual screening and propose a mechanism for its inhibitory activity.

Graphical abstract: Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 17 Nov 2011, accepted on 06 Jan 2012 and first published on 10 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC17158A
Citation: Chem. Commun., 2012,48, 2412-2414
  •   Request permissions

    Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening

    G. Kumar, R. Agarwal and S. Swaminathan, Chem. Commun., 2012, 48, 2412
    DOI: 10.1039/C2CC17158A

Search articles by author