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Issue 24, 2012
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Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

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Abstract

The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.

Graphical abstract: Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

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Publication details

The article was received on 16 Nov 2011, accepted on 21 Jan 2012 and first published on 23 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC17118J
Citation: Chem. Commun., 2012,48, 2976-2978
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    Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

    J. Madine, H. A. Davies, C. Shaw, I. W. Hamley and D. A. Middleton, Chem. Commun., 2012, 48, 2976
    DOI: 10.1039/C2CC17118J

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